Expression and clinical significance of gastrin in the process of gastric mucosa carcinogenesis

Publication Date : 16/07/2015


Author(s) :

Zhi-Yong Wang , Jin-long Fu , Jian-liang Wu , Li-wei Sun , Yun Guo , Guo-xiong Li.


Volume/Issue :
Volume 1
,
Issue 7
(07 - 2015)



Abstract :

[abstract] Objective: To investigate serum gastrin expression and clinical significance in carcinogenesis of gastric mucosa. Methods: H. pylor was measured by the rapid urease enzyme test,Warthin-Starry silver stain and/or 14C-urea breath test. Serum gastrin in 412 cases of patients with carcinogenesis of gastrine mucosa was measured using radioimmunoassay analysis; Results: H. pylori-positive group, serum gastrin was higher than H. pylori-negative group (P<0.05); Serum gastrin in the process of gastric mucosa carcinogenesis was higher than that in gastric cancer groups (P<0.05). Conclusion: Serum gastrin is a better marker to identify the stomach of benign and malignant disease; therefore, detecting GAS serum levels of patients with intraepithelial neoplasia will be very valuable to diagnosis, for example, when GAS significantly declines, it is necessary to consider the possibility of disease progression.


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