Phyto-chemical Characterisation and Evaluation of Neuropharmacological Activities of Mallotus Philippensis (Lamk) Muell. Arg.

Publication Date : 31/03/2015


Author(s) :

Sindhu K , Sujith S , Jacob M , Juliet, S , Suja R S.


Volume/Issue :
Volume 1
,
Issue 3
(03 - 2015)



Abstract :

The Central nervous system activity of Mallotus phillipensis was assessed in rats taking into consideration the effect on the spontaneous and forced motor activity. The leaves of the plant collected locally were extracted using methanol and water. The phytochemical analysis of various extracts was done using standard techniques. The central nervous system activity of the extract at 250 mg/kg body weight orally was assessed based on the effect on general behavioral pattern and the effect on spontaneous and forced motor activity using digital photoactameter, Rota rod apparatus respectively and compared with diazepam @ 1 mg/kg. The acute oral toxicity of the extract was assessed in rats at limit dose of 2000 mg/kg. Phytochemical analysis revealed the presence of phenolics, alkaloids, glycosides, tannins, terpenes and flavonoids in the extract. The extract in general reduced the spontaneous activity, alertness and awareness, but the effect was not as pronounced as that of diazepam. The forced motor and spontaneous motor activities were depressed better than diazepam and aqueous extract. From the study it could be concluded that the methanolic extract of M. philippensis at 250 mg/kg B.W. was safe depressant of the CNS.


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