Outbreaks of turkey pox were reported in unvaccinated turkey poults of 6th, 8th and 10th week old in three organized turkey farms. Affected birds showed both cutaneous and diphtheritic form of pox lesions. Several coalescing, round nodular lesions were found in the eyelids, head, wattles and legs and some were superficially ulcerated. Post mortem examination revealed diphtheritic necrotic membranes lining the oral cavity and upper respiratory system in all the birds and intestinal congestion with severe tape worm infestation in the birds of third farm. Histopathological examination of the skin lesions showed large clusters of hypertrophic and hyperplastic epidermal stratified squamous epithelium, surrounded by dense fibroblastic stroma, swollen pale keratinocytes with a foamy, vacuolated cytoplasm and Bollinger bodies. Based on the clinical, post mortem and histopathological examination the disease outbreaks were confirmed as turkey pox. Adviced to apply paste of neem leaves and turmeric externally and to give microsol antibiotic powder @ 4 gm/ litre of drinking water along with B- complex vitamin for 5 days. All the birds were given deworming with L-Mizole (Levamisole and Metronidazole) @ 10mg/100 birds in drinking water. Clinical signs in the affected birds disappeared completely in 6 weeks.
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