Acute lymphocytic Leukemia was diagnosed in a seven year old, male, golden retriever dog that was presented with clinical signs such as anorexia, exercise intolerance, edema of hind limbs, edema of scrotum, tachycardia and pale mucus membranes. The case was diagnosed based on hematology and cytology of buffy coat. Blood smear and buffy coat smears revealed 100% lymphocytosis with lymphoblasts and prolymphocytes and complete absence of other leukocytes.
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