Study of Haemoglobinopathies incidence in Ogbonicha District-Ofu LGA, Kogi State, Nigeria.

Publication Date : 12/03/2016


Author(s) :

Obisesan OA , Ogundeko T.O , Nyango J , Ojochenemi JC , Ajala EK , Bassi AP , Iheanacho C , Ntuhun B , Orji R , Olorunfunmi JS.


Volume/Issue :
Volume 2
,
Issue 3
(03 - 2016)



Abstract :

Abstract Background: Haemoglobinopathy is associated with different pathological conditions especially in Africa and other third world countries. This genetically determined blood disorder has posed continued alarming problem in public health especially in Africa and other third world countries. Many Nigerians are yet to have clear understanding of the generation, presentations and management of Haemoglobinopathies perhaps due to their religion or cultural beliefs. Sequel to this problem, it is imperative to provide adequate information for prompt intervention in order to curb the situation. Study provides information on the incidence of same in Ogbonicha District of Ofu Local Government Area, Kogi State, Nigeria. Methods: A total number of 400 volunteered people and were screened for haemoglobin (Hb) variants by alkaline cellulose acetate electrophoresis. Results: Out of the 400 subjects that were screened regardless of age and status, 222 (55.50%) were females and 178 (44.50%) were males. Only three (3) Hb genotypes HbAA (76.50%), HbAS (22.25%) and HbSS (1.25%) were reported in this study. In female, the sickle-cell-trait (HbAS) was 94.37% (67) while the disease state (HbSS) was 5.63% (4) while in males; the sickle-cell-trait was 95.65% (22) and the disease state 4.35% (1). Conclusion: The high prevalence of HbAA with the observed low prevalence of HbSS variants in this population could imply a decline in haemoglobinopathy in the population. However mass literacy campaign and improved counseling on related genetic issues should be encouraged and maintained in order to eradicate haemoglobinopathy. Keywords: haemoglobinopathy, genotypes, gender, Ogbonicha- Nigeria.


No. of Downloads :

8