EFFECTS OF ‘CITRULLUS COLOCYNTHIS’ AND ‘CUCUMIS CALLOSUS’ ON ORAL GLUCOSE TOLERANCE TEST
Publication Date : 18/07/2016
The term diabetes was probably derived by Apollonius of Memphis around 250 BC. Diabetes is first recorded in English, in the form diabete. Diabetes mellitus is derived from the Greek word diabetes meaning siphon – (pass through) and the Latin word mellitus meaning honeyed or sweet. This is because in diabetes excess sugar is found in blood as well as the urine. The oral glucose tolerance test (OGTT) is vital for the characterization of metabolic syndrome, the natural evolution from prediabetes to Type-2 diabetes, and characterization of the metabolic actions of cardiovascular and metabolic drugs. Although the OGTT is rarely used as a diagnostic test for Type-2 diabetes it is widely used as a sensitive indicator of gestational diabetes. Phytochemical screening revealed that the fruits of C. colocynthis L. and C. callosus L. contain tertiary and quaternary alkaloids, glycoside, carbohydrates and saponin components. These results suggest that the ethanolic extract of fruits of C. colocynthis L. and C. callosus L. possesses oral hypoglycemic effect and its combination (C. colocynthis and C. callosus) produced synergistic action at same dose.
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