Studies on the liver histology and biochemistry due to pesticide exposure in rats inhabiting vegetable crop fields
Publication Date : 25/07/2016
Extensive and indiscriminate use of pesticides on crops poses a health hazard but scarce information is available on the effects of these pesticides on non-target mammalian species in field conditions. Rats were collected from the vegetable fields, sacrificed and the liver was excised for histological and biochemical analysis. The histological observations of the liver, showed slight loosening in the arrangement of hepatic cords around central vein, the loss of radial arrangements of hepatocytes and areas where normal parenchyma was replaced by large blood filled spaces. The mean diameter of central vein of (17.21µm) and (16.15µm) in male rats and (15.70µm) and (17.00µm) in female rats showed significant increase as compared to control during winter and summer seasons respectively. The total protein and total lipid content in the liver of female rats increased significantly, while the level of cholesterol increased significantly in the liver of males during summer season. During the winter season there was a marked increase in Acid Phosphatase (ACP) activity in male and female field rats. ACP activity is essential in the formation of ATP as an energy source, and an alteration in the enzyme may be attributed to cellular leakage causes by chemical induced stress of the tissue. The results indicate that the persistent exposure to a variety of pesticides coupled with environmental conditions caused aberrations in liver structure and function leading to physiological stress through biochemical pathways. There is a strong indication of these variations being gender specific and environmental dependent.
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