Synthesis, characterisation and screening of some new chlorosubstituted imidazolo-pyrazolines with special reference to their growth promoting and curative impact on Oyster mushroom crop
Publication Date : 02/07/2016
Five membered heterocycles with an additional hetero-atom called azoles are well known for their pharmacological, agricultural and industrial applications. The chemotherapeutic agents such as orisul (bacterostatic), antipyrine (antipyretic), butazolidine (anti-inflammatory) contain pyrazoline nucleus. They have remarkable insecticidal activity against the insects like lepidopteran and coleopteran. Imidazole derivatives of pyrazoline substrates were also reported as main constituents of many pesticides used in agriculture. Some of their derivatives show the fungicidal and plant growth regulatory activities. Owing to their applications, a significant amount of research activity has been directed towards synthesis of this class of compounds. In this context, synthesis of some new chlorosubstituted 1-phenyl-3-(2-substitiuted-5-chlorophenyl)-4-benzoyl-5-[2-mercapto-4-(2’-hydroxy-5’-chlorophenyl)-imidazolo]-4,5-dihydro-Δ2-pyrazolines were undertaken from 1-phenyl-3-(2-hydroxy-5-chlorophenyl)-4-benzoyl-5-amino-4,5-dihydro-Δ2-pyrazoline, which was prepared by the reaction of substituted-3-benzoyl-6-chloroflavanone with phenylhydrazine hydrochloride in 1,4-dioxane containing a little piperidine. The structures of newly synthesised compounds were determined on the basis of elemental analysis and spectral characterization. The newly synthesised compounds were assayed for their antimicrobial activity against some fungi viz. Gliocladium roseum (Link) Bainier, Verticillium fungicola and some bacteria viz. Pseudomonas stutzeri, Pseudomonas alcaligens, Pseudomonas fluorescene, Burkholderia gladioli which are mainly responsible for the damage of mushroom crop. So also the titled compounds were screened for their impact on phytotic growth of Oyster mushroom spp.
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