Effect of aqueous extract of basil (ocimum basilicum) leaves on nephrotoxicity induced by adriamycin in male rats: histological and immunohistochemical assessment

Publication Date : 05/04/2017

DOI : 10.22623/IJAPSA.2017.3014.6ZXBN


Author(s) :

Rania A. Ahmed , Hany A. Abdel Samie.


Volume/Issue :
Volume 3
,
Issue 3
(04 - 2017)



Abstract :

Adriamycin, is a widely utilized anticancer drug applicable in number of human malignancies. Adriamycin exerted considerable effects in many organs that possibly hamper its utilization. The beneficial action of the natural plant basil was proven against many aliments. The present work studied the effect of aqueous extract of basil (ocimum basilicum) on adriamycin -induced nephrotoxicity in rats.Administration of Adriamycin intraperitoneally resulted in nephrotoxicity manifested as enlargement and congestion of blood vessels in the kidney, occurrence of vacuolated cells, shrinkage of glomeruli, edema and leucocytic infiltration and appearance of proteinous casts in kidney tubules. Immunohistochemically, adriamycin caused elevated expression of bax and α-SMA in renal cells. Adriamycin treatment induced serum urea and creatinine increase. Treatment with basil extract with adriamycin lowered the abnormalities decreased the pro-apoptotic protein, bax and fibrosis marker, α-SMA. Again, basil moved the levels of serum urea and creatinine towards normal. In conclusion, basil offered protectively against nephrotoxicity of adriamycin in male albino rats.


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