LIPID PEROXIDATION INDUCED NUCLEIC ACID DAMAGE IN LIVER AND BRAIN OF BISPHENOL-A TREATED CHICK EMBRYOS
Publication Date : 02/06/2017
A study was conducted on effect of Bisphenol-A (BPA) toxicity on nucleic acid damage during embryonic development in chicks. Bisphenol-A dissolved in distilled water in three concentrations of 100µM, 250µM and 500µM injected into the aircell separately to 11th and 14th day old chick embryos. Embryos were sacrificed after 24 and 48 hours of BPA exposure to collect liver and brain tissues for estimation of Thiobarbituric acid reacting substances (TBARS) and nucleic acids (DNA & RNA). A dose dependent decrease in DNA levels was observed in all treatment groups after 24 hours in both 11th and 14th day BPA treated chick embryos compared to control. A significant dose dependent decrease in RNA levels was observed after BPA exposure after 24 hours in both 11th and 14thday BPA treated chick embryos compared to control.
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