Anticancer activity of Co doped ZnS nanoparticles synthesized by chemical method

Publication Date : 26/12/2018

DOI : 10.22623/IJAPSA.2018.4041.ERRPS


Author(s) :

Dr .N. Manivannan. , Dr.B.ChandarShekar , Dr.C.K.Senthilkumaran.


Volume/Issue :
Volume 4
,
Issue 11
(12 - 2018)



Abstract :

Co doped ZnS nanoparticles were prepared by a simple chemical precipitation method. Zinc blende structure is confirmed by X-ray diffraction (XRD) analysis. The surface morphology and chemical compositions of material were recorded by SEM with EDAX.. High Resolution Transmission Electron (HRTEM) micrographs showed the confirmation of particle size around 2nm. The results from selected area electron diffraction (SAED) consistent the XRD results . In FTIR spectra the peaks formed at 616-1103 cm-1 are attributed to the bond between cobalt and sulphur. The magnetization (M -H curve) measured at room temperature exhibited saturated hysteresis loop for higher Co concentration exhibit at room temperature indicating ferromagnetism where as samples having higher Co concentrations showed such saturation confirming the strong ferromagnetism of the sample. Anticancer properties of the Co doped ZnS nanoparticles showed a direct dose response relationship and activity increased at higher concentrations level. Invirto anticancer study of Co doped ZnS nanoparticles against HT 29 colon cancer cell lines revealed significant anticancer effect and concentration dependent inhibition.


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