IN VITRO ANTIOXIDANT ACTIVITY OF METHANOL EXTRACT OF ERYTHRINA VARIEGATA STEM BARK

Publication Date : 09/04/2018

DOI : 10.22623/IJAPSA.2018.4015.AIGMV


Author(s) :

Reni John , Bibu John Kariyil , Usha P. T. A..


Volume/Issue :
Volume 4
,
Issue 3
(04 - 2018)



Abstract :

Erythrina variegata leaves and bark are being used traditionally for the treatment of several diseases. In the present study, the methanol extract of Erythrina variegata stem bark has been assessed for the presence of phytochemicals and in vitro antioxidant activity by means of DPPH free radical and nitric oxide (NO) radical scavenging assays. Phytochemical analysis revealed the presence of flavonoids, glycosides, alkaloids, tannins, steroids, phenolics and diterpenes Methanol extract of Erythrina variegata stem bark exhibited marked scavenging activity against DPPH and NO free radicals in a dose dependent manner comparable to the effect produced by vitamin C standard. The EC50 value for DPPH free radical inhibition by the methanol extract of Erythrina variegata stem bark was 45.86±5. 85μg/mL whereas for nitric oxide radical inhibition, EC50 obtained was 28.14±3.42. Hence the present study identified that the methanol extract of Erythrina variegata stem bark possessed marked antioxidant activity in a dose dependent manner.


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